Comprehensive set of standard operating procedure for long-term care facilities covering: 1) infection prevention, 2) testing and screening, 3) managing infection/outbreak, and 4) broader policies and planning. This document aggregates useful information, offering detailed step-by-step procedures, examples and scenarios and taking into account variations in resource availability and government support. It also draws on the experience of managing an outbreak at Highlands House care, a nursing home in Cape Town, South Africa. This document was developed in South Africa and makes some reference to South Africa in terms of testing procedures but operating procedures should have general applicability in other Low and Middle Income Countries. Care facilities may need to adapt these procedures to their individual circumstances, budgets and operating models.